Mariana Mazzucato’s work on the relationship between innovation and the direction of economic growth is having global impact. In the last years she has been key to bringing a mission oriented lens to EU Innovation policy, steering the UK’s industrial policy, helping to create a new roadmap for the UN’s Sustainable Development Goals, and informing the restructuring of development finance institutions. In particular, she has brought ‘mission-oriented’ at the heart of economic policy. Her roles include being a Special Economic Adviser to the Italian Prime Minister; Member of South African President Ramaphosa’s Economic Advisory Group; member of the Vatican’s COVID-19 commission; a member of the Scottish Government’s Council of Economic Advisors; a member of the World Economic Forum Global Future Council of the New Economic Agenda, and more. Through her role as Special Advisor for the EC Commissioner for Research, Science and Innovation (2017-2019), she authored the high impact report on Mission-Oriented Research & Innovation in the European Union, turning “missions” into a crucial new instrument in the European Commission’s Horizon innovation programme.